RNF223

Across TCGA cell cohorts, RNF223 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RNF223-associated genes across cancer lineages are SPATA31D1 and C1orf232. Each is linked with RNF223 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF223-to-partner and partner-to-RNF223 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31D1 grouped by RNF223-low versus RNF223-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF223→partner) and Y-score (partner→RNF223) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPATA31D1 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	C1orf232 →	+0.037	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

SPATA31D1 by RNF223 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →