Across TCGA pan-cancer cohorts, RNF222 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated RNF222 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher RNF222 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RNF222 expression acts as an unfavorable survival marker.

BRCA are the cancer types where RNF222 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.434	0.924	<.001	30	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: RNF222 tumor-vs-normal RNA expression · all RNF222 data types