Across TCGA cell cohorts, RNF222 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,894 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF222-associated GO terms across cancer lineages are NMDA selective glutamate receptor signaling pathway, Establishment of epithelial cell apical/basal polarity, and Regulation of ruffle assembly. Each is linked with RNF222 in more than 9 cancer types. Because this analysis shows association rather than direction, both RNF222-to-partner and partner-to-RNF222 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF222→partner) and Y-score (partner→RNF222) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NMDA selective glutamate receptor signaling pathway →	+0.230	+0.152	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Establishment of epithelial cell apical/basal polarity →	-0.147	-0.424	<.001	<.001	3	8
LUNG_NSCLC_LUAD	Regulation of ruffle assembly →	+0.177	+0.562	<.001	.002	3	8
BONE	Regulation of pattern recognition receptor signaling pathway →	+0.061	+0.046	<.001	<.001	3	8
BONE	Regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.058	+0.045	<.001	<.001	3	8
OESOPHAGUS	Golgi vesicle budding →	+0.149	+0.295	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,894 associations by consensus.

Exploration

RNF222 survival (RNA) · tumor vs normal (RNA) · all RNF222 data types