Across TCGA patient cohorts, RNF220 mutation is significantly associated with the RNA expression of many other genes, with 4,669 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF220-associated genes across cancer lineages are CENPU, MED8, and ZMYND19. Each is linked with RNF220 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF220-to-partner and partner-to-RNF220 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF220→partner) and Y-score (partner→RNF220) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.618	+2.202	<.001	<.001	3	3
UCEC	MED8 →	+0.297	+2.900	.001	<.001	3	3
SKCM	ZMYND19 →	+0.597	+3.372	<.001	.004	3	3
UCEC	SLC25A33 →	+0.607	+1.903	<.001	<.001	3	3
UCEC	RAD51 →	+0.899	+2.868	<.001	<.001	3	3
UCEC	MSANTD3 →	+0.689	+3.964	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,669 associations by consensus.

Exploration

RNF220 survival (RNA) · tumor vs normal (RNA) · all RNF220 data types