RNF216

Across TCGA patient cohorts, RNF216 protein abundance is significantly associated with the RNA expression of many other genes, with 4,522 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RNF216-associated genes across cancer lineages are WIPI2, MIOS, and PMS2CL. Each is linked with RNF216 in more than 3 cancer types. Because this analysis shows association rather than direction, both RNF216-to-partner and partner-to-RNF216 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF216 versus WIPI2 in LUAD, with a Pearson correlation of 0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF216→partner) and Y-score (partner→RNF216) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	WIPI2 →	+0.434	+0.261	<.001	<.001	3	4
LUAD	MIOS →	+0.467	+0.303	<.001	.001	3	4
LUAD	PMS2CL →	+0.396	+0.215	<.001	.009	3	4
LSCC	ZFAND2A-DT →	+0.633	+0.328	<.001	<.001	3	4
LSCC	BRAT1 →	+0.596	+0.307	<.001	<.001	3	3
LUAD	PLEKHA8 →	+0.591	+0.230	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,522 associations by consensus.

RNF216 vs WIPI2 — LUAD

Explore this scatter interactively →