RNF216

Across TCGA patient cohorts, RNF216 mutation is significantly associated with the RNA expression of many other genes, with 2,928 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF216-associated genes across cancer lineages are CDK8P1, MTCO2P23, and CRACDL. Each is linked with RNF216 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF216-to-partner and partner-to-RNF216 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK8P1 grouped by RNF216-low versus RNF216-high in SARC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF216→partner) and Y-score (partner→RNF216) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	CDK8P1 →	+0.083	+5.778	<.001	.003	3	3
OV	MTCO2P23 →	+0.085	+5.297	<.001	.006	3	3
BLCA	CRACDL →	-0.885	-2.964	.001	.001	3	3
LUSC	RNA5SP412 →	+0.422	+4.578	<.001	.005	3	3
STAD	RNA5SP477 →	+0.768	+3.626	.003	.003	3	3
STAD	SAR1AP3 →	+0.109	+3.544	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,928 associations by consensus.

CDK8P1 by RNF216 expression — SARC

Explore this box plot interactively →