RNF216

Across TCGA patient cohorts, RNF216 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF216-associated genes across cancer lineages are PRAS40_pT246, Caspase-7-cleavedD198, and PKC-a_pS657. Each is linked with RNF216 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF216-to-partner and partner-to-RNF216 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by RNF216-low versus RNF216-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF216→partner) and Y-score (partner→RNF216) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.189	+1.820	.007	.016	3	3
UCEC	Caspase-7-cleavedD198 →	+0.846	+1.807	<.001	.027	3	3
BLCA	PKC-a_pS657 →	-0.335	-3.321	.014	.009	3	2
UCEC	GAPDH →	+0.747	+3.459	<.001	.005	3	2
UCEC	Mre11 →	-0.098	-3.432	.005	.005	3	2
UCEC	RBM15 →	+0.351	+3.584	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

PRAS40_pT246 by RNF216 expression — UCEC

Explore this box plot interactively →