RNF216

Across TCGA cell cohorts, RNF216 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,672 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF216-associated GO terms across cancer lineages are Meiotic attachment of telomere to nuclear envelope, Meiotic telomere tethering at nuclear periphery, and Meiotic telomere clustering. Each is linked with RNF216 in more than 16 cancer types. Because this analysis shows association rather than direction, both RNF216-to-partner and partner-to-RNF216 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic attachment of telomere to nuclear envelope grouped by RNF216-low versus RNF216-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF216→partner) and Y-score (partner→RNF216) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Meiotic attachment of telomere to nuclear envelope →	+0.167	+0.953	<.001	<.001	3	17
BLOOD_Lymphoma	Meiotic telomere tethering at nuclear periphery →	+0.167	+0.953	<.001	<.001	3	17
BLOOD_Lymphoma	Meiotic telomere clustering →	+0.167	+0.953	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of hippo signaling →	+0.072	+0.995	<.001	.001	3	16
BLOOD_Lymphoma	Positive regulation of isotype switching to IgG isotypes →	+0.119	+1.077	.002	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.080	+0.769	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,672 associations by consensus.

Meiotic attachment of telomere to nuclear envelope by RNF216 expression — BLOOD_Lymphoma

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