RNF213

Across TCGA pan-cancer cohorts, RNF213 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated RNF213 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher RNF213 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RNF213 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

THYM, UCEC, and KIRP are the cancer types where RNF213 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.135	0.888	<.001	48	view →
UCEC	DFS	Median	All	0.809	0.605	.002	28	view →
KIRP	OS	Median	All	0.111	0.897	<.001	24	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
ESCA	DFS	Median	All	0.239	0.547	.001	9	view →
SKCM	DFS	Median	II,III,IV	0.856	0.658	.020	5	view →
LUAD	DFS	Median	All	0.924	0.661	.037	4	view →
LGG	OS	Median	All	0.307	0.799	.035	3	view →
COAD	OS	Median	IV	0.140	0.657	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

RNF213–THYM (OS)

Open the THYM breakdown →