RNF213

Across TCGA pan-cancer cohorts, RNF213 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RNF213’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where RNF213 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RNF213 is over-expressed in tumor.

CCRCC, HNSC, and COAD are the cancer types where RNF213 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF213 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.665	<.001	12	view →
HNSC	Male	IV	+0.883	<.001	11	view →
COAD	Female	III,IV	+0.518	<.001	11	view →
PDAC	Female	All	+0.735	<.001	9	view →
LUAD	Female	II,III,IV	+0.530	<.001	9	view →
LSCC	Female	All	+0.375	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RNF213–CCRCC

Open the CCRCC breakdown →