RNF213

Across TCGA patient cohorts, RNF213 mutation is significantly associated with the total protein of many other genes, with 129 significant associations in total. COAD shows the largest number of these associations.

The most reproducible RNF213-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and ASNS. Each is linked with RNF213 in more than 5 cancer types. Because this analysis shows association rather than direction, both RNF213-to-partner and partner-to-RNF213 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RNF213-low versus RNF213-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF213→partner) and Y-score (partner→RNF213) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.327	+2.288	<.001	<.001	3	6
UCEC	ATM →	-0.423	-1.904	<.001	<.001	3	5
COAD	ASNS →	+0.418	+1.640	<.001	<.001	3	5
STAD	GAPDH →	+0.455	+2.523	<.001	<.001	3	4
COAD	Lck →	+0.374	+1.855	<.001	<.001	3	4
STAD	NF2 →	+0.161	+1.906	.001	.011	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 129 associations by consensus.

Caspase-7-cleavedD198 by RNF213 expression — COAD

Explore this box plot interactively →