RNF213

Across TCGA cell cohorts, RNF213 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,338 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RNF213-associated GO terms across cancer lineages are Xenophagy, Negative regulation of non-canonical Wnt signaling pathway, and Macroautophagy. Each is linked with RNF213 in more than 19 cancer types. Because this analysis shows association rather than direction, both RNF213-to-partner and partner-to-RNF213 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Xenophagy grouped by RNF213-low versus RNF213-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF213→partner) and Y-score (partner→RNF213) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Xenophagy →	+0.222	+1.502	<.001	.001	3	20
BLOOD_Lymphoma	Negative regulation of non-canonical Wnt signaling pathway →	+0.526	+2.493	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Macroautophagy →	+0.075	+1.638	.005	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Vacuolar transport →	+0.063	+1.690	<.001	<.001	3	16
SOFT_TISSUE	Regulation of macroautophagy →	+0.055	+1.352	<.001	<.001	3	14
OVARY	Intracellular receptor signaling pathway →	+0.057	+1.481	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,338 associations by consensus.

Xenophagy by RNF213 expression — LIVER

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