RNF212

Across TCGA patient cohorts, RNF212 mutation is significantly associated with the RNA expression of many other genes, with 2,092 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF212-associated genes across cancer lineages are RNU6-1060P, RNA5SP422, and CISD3. Each is linked with RNF212 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF212-to-partner and partner-to-RNF212 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1060P grouped by RNF212-low versus RNF212-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF212→partner) and Y-score (partner→RNF212) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	RNU6-1060P →	+0.568	+7.939	<.001	.008	3	2
SKCM	RNA5SP422 →	+0.283	+7.816	<.001	.008	3	2
UCEC	CISD3 →	+0.499	+3.523	.002	<.001	3	1
UCEC	IGLV2-8 →	+1.509	+2.000	.001	.003	3	1
UCEC	H2AC4 →	+0.548	+2.885	<.001	<.001	3	1
UCEC	DHRS11 →	+0.536	+2.186	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,092 associations by consensus.

RNU6-1060P by RNF212 expression — PRAD

Explore this box plot interactively →