Across TCGA patient cohorts, RNF208 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible RNF208-associated genes across cancer lineages are NDUFA5P4, RNU6-1131P, and NPIPA2. Each is linked with RNF208 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF208-to-partner and partner-to-RNF208 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF208→partner) and Y-score (partner→RNF208) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NDUFA5P4 →	+0.110	+6.111	<.001	.002	3	2
SKCM	RNU6-1131P →	+0.328	+7.816	<.001	.008	3	2
BLCA	NPIPA2 →	+0.029	+7.640	<.001	.009	3	1
BRCA	RNU7-29P →	+1.312	+8.055	<.001	.007	3	1
BRCA	MIR3689D2 →	+0.332	+8.055	<.001	.007	3	1
BRCA	CLPTM1LP1 →	+0.189	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

RNF208 survival (RNA) · tumor vs normal (RNA) · all RNF208 data types