RNF20

Across TCGA patient cohorts, RNF20 mutation is significantly associated with the RNA expression of many other genes, with 2,962 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF20-associated genes across cancer lineages are GPATCH11, DENND10, and TIPIN. Each is linked with RNF20 in more than 3 cancer types. Because this analysis shows association rather than direction, both RNF20-to-partner and partner-to-RNF20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPATCH11 grouped by RNF20-low versus RNF20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF20→partner) and Y-score (partner→RNF20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPATCH11 →	+0.475	+2.868	<.001	<.001	3	4
SKCM	DENND10 →	+0.476	+3.591	.005	.001	3	3
SKCM	TIPIN →	+0.592	+3.207	.003	.009	3	3
STAD	RNU6-1067P →	+0.667	+4.290	<.001	.008	3	3
UCEC	NDUFB6 →	+0.401	+2.818	.001	.001	3	3
UCEC	ENTR1 →	+0.319	+2.601	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,962 associations by consensus.

GPATCH11 by RNF20 expression — UCEC

Explore this box plot interactively →