RNF2

Across TCGA patient cohorts, RNF2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF2-associated genes across cancer lineages are c-Met_pY1235, 14-3-3_beta, and EGFR_pY1068. Each is linked with RNF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF2-to-partner and partner-to-RNF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by RNF2-low versus RNF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF2→partner) and Y-score (partner→RNF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.076	+2.000	.011	.029	3	2
UCEC	14-3-3_beta →	-0.096	-3.143	.017	.018	3	1
UCEC	EGFR_pY1068 →	-0.313	-1.906	.001	.016	3	1
UCEC	GAPDH →	+0.464	+3.321	.031	.010	3	1
UCEC	GATA6 →	-0.189	-1.992	.006	.031	3	1
UCEC	ACC1 →	+0.393	+2.183	.007	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

c-Met_pY1235 by RNF2 expression — UCEC

Explore this box plot interactively →