RNF186

Across TCGA patient cohorts, RNF186 mutation is significantly associated with the RNA expression of many other genes, with 951 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF186-associated genes across cancer lineages are RNU6-871P, OR4X2, and TMEM252-DT. Each is linked with RNF186 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF186-to-partner and partner-to-RNF186 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-871P grouped by RNF186-low versus RNF186-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF186→partner) and Y-score (partner→RNF186) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-871P →	+0.766	+5.159	<.001	.007	3	3
LUSC	OR4X2 →	+0.098	+5.438	<.001	.002	3	2
UCEC	TMEM252-DT →	+0.336	+2.867	.008	.004	3	2
BLCA	C9orf62 →	+0.032	+6.618	<.001	.001	3	2
LUSC	COX6B1P7 →	+0.617	+5.309	<.001	.003	3	2
LUSC	MTCO2P23 →	+0.292	+5.733	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 951 associations by consensus.

RNU6-871P by RNF186 expression — SKCM

Explore this box plot interactively →