RNF186

Across TCGA patient cohorts, RNF186 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF186-associated genes across cancer lineages are JNK2, Ku80, and MSH2. Each is linked with RNF186 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF186-to-partner and partner-to-RNF186 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by RNF186-low versus RNF186-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF186→partner) and Y-score (partner→RNF186) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.253	+2.321	.011	.035	3	1
UCEC	Ku80 →	+0.304	+2.335	.010	.020	3	1
UCEC	MSH2 →	-0.384	-2.973	<.001	.035	3	1
UCEC	p62 Lck ligand →	+0.376	+2.179	.021	.034	3	1
UCEC	PCNA →	+0.276	+3.169	.010	.019	3	1
UCEC	Rictor_pT1135 →	-0.125	-2.321	.015	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK2 by RNF186 expression — UCEC

Explore this box plot interactively →