RNF186

Across TCGA cell cohorts, RNF186 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,541 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF186-associated GO terms across cancer lineages are Tissue homeostasis, Anatomical structure homeostasis, and Serotonin biosynthetic process. Each is linked with RNF186 in more than 6 cancer types. Because this analysis shows association rather than direction, both RNF186-to-partner and partner-to-RNF186 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tissue homeostasis grouped by RNF186-low versus RNF186-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF186→partner) and Y-score (partner→RNF186) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Tissue homeostasis →	+0.056	+0.857	<.001	<.001	3	7
LARGE_INTESTINE	Anatomical structure homeostasis →	+0.056	+0.857	<.001	<.001	3	7
LIVER	Serotonin biosynthetic process →	+1.652	+0.090	<.001	.002	2	6
LIVER	Negative regulation of T cell mediated cytotoxicity →	+2.150	+0.136	<.001	.003	3	5
LIVER	Renal D-glucose absorption →	+1.530	+0.093	<.001	.005	3	5
LIVER	Branched-chain amino acid transport →	+0.231	+0.100	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,541 associations by consensus.

Tissue homeostasis by RNF186 expression — LARGE_INTESTINE

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