RNF185

Across TCGA pan-cancer cohorts, RNF185 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNF185 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RNF185 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF185 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where RNF185 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.706	0.907	.002	25	view →
HNSC	DFS	Quartile	All	0.824	0.478	.002	23	view →
CCRCC	DFS	Quartile	All	0.591	0.947	.013	15	view →
LSCC	DFS	Median	All	0.614	0.811	.022	3	view →
GBM	DFS	Median	All	0.302	0.435	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RNF185–PDAC (DFS)

Open the PDAC breakdown →