RNF185

Across TCGA patient cohorts, RNF185 mutation is significantly associated with the RNA expression of many other genes, with 150 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF185-associated genes across cancer lineages are GJA6P, RN7SL210P, and RNA5SP478. Each is linked with RNF185 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF185-to-partner and partner-to-RNF185 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJA6P grouped by RNF185-low versus RNF185-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF185→partner) and Y-score (partner→RNF185) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	GJA6P →	+0.070	+4.187	.001	.009	3	2
LUSC	RN7SL210P →	+0.212	+5.517	<.001	<.001	3	2
SKCM	RNA5SP478 →	+0.182	+5.485	<.001	.001	3	2
CESC	OR51V1 →	+0.037	+5.969	<.001	.002	3	1
CESC	CCT8L2 →	+0.025	+5.969	<.001	.002	3	1
CESC	RN7SKP118 →	+0.138	+5.103	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 150 associations by consensus.

GJA6P by RNF185 expression — LUSC

Explore this box plot interactively →