RNF183

Across TCGA patient cohorts, RNF183 mutation is significantly associated with the RNA expression of many other genes, with 134 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible RNF183-associated genes across cancer lineages are SNX3P1X, RNA5SP408, and RNU6-1321P. Each is linked with RNF183 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF183-to-partner and partner-to-RNF183 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNX3P1X grouped by RNF183-low versus RNF183-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF183→partner) and Y-score (partner→RNF183) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNX3P1X →	+0.329	+7.930	<.001	.008	3	2
UCEC	RNA5SP408 →	+0.414	+3.186	.001	.008	3	2
COAD	RNU6-1321P →	+0.744	+4.510	.001	.005	3	2
UCEC	TEX36-AS1 →	+0.156	+2.776	.005	.005	3	2
SKCM	OR11H12 →	+0.029	+4.199	<.001	.009	3	2
UCEC	RNA5SP414 →	+0.826	+2.933	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 134 associations by consensus.

SNX3P1X by RNF183 expression — LUAD

Explore this box plot interactively →