RNF183

Across TCGA cell cohorts, RNF183 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,406 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RNF183-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Cellular response to ketone, and Positive regulation of gastrulation. Each is linked with RNF183 in more than 8 cancer types. Because this analysis shows association rather than direction, both RNF183-to-partner and partner-to-RNF183 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by RNF183-low versus RNF183-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF183→partner) and Y-score (partner→RNF183) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.080	+2.332	<.001	<.001	3	9
LARGE_INTESTINE	Cellular response to ketone →	+0.062	+0.697	.005	.002	2	8
LUNG_SCLC	Positive regulation of gastrulation →	-0.255	-2.120	.003	.003	3	7
OESOPHAGUS	Positive regulation of autophagy →	+0.054	+0.289	<.001	.004	2	8
LUNG_SCLC	Regulation of myoblast fusion →	+0.077	+2.667	.004	<.001	3	7
LUNG_SCLC	Regulation of nucleocytoplasmic transport →	+0.057	+1.785	.004	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,406 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by RNF183 expression — LUNG_SCLC

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