RNF183

Across TCGA cell cohorts, RNF183 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF183-associated genes across cancer lineages are CRISP1, DEFA4, and C1QTNF7. Each is linked with RNF183 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF183-to-partner and partner-to-RNF183 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRISP1 grouped by RNF183-low versus RNF183-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF183→partner) and Y-score (partner→RNF183) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRISP1 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	DEFA4 →	+0.040	+5.022	<.001	.002	3	1
LARGE_INTESTINE	C1QTNF7 →	+0.120	+4.108	<.001	.008	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CRISP1 by RNF183 expression — LARGE_INTESTINE

Explore this box plot interactively →