RNF181

Across TCGA pan-cancer cohorts, RNF181 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNF181 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RNF181 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF181 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where RNF181 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.391	0.796	.004	27	view →
PDAC	OS	Median	III,IV	0.170	0.688	<.001	20	view →
HNSC	DFS	Tertile	All	1.000	0.623	.040	6	view →
GBM	OS	Tertile	All	0.783	0.897	.013	5	view →
LSCC	OS	Tertile	II,III,IV	0.829	0.955	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RNF181–CCRCC (DFS)

Open the CCRCC breakdown →