RNF181

Across TCGA patient cohorts, RNF181 protein abundance is significantly associated with the RNA expression of many other genes, with 8,202 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible RNF181-associated genes across cancer lineages are CHD6, GGCX, and LRRC49. Each is linked with RNF181 in more than 4 cancer types. Because this analysis shows association rather than direction, both RNF181-to-partner and partner-to-RNF181 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF181 versus CHD6 in HNSC, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF181→partner) and Y-score (partner→RNF181) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CHD6 →	-0.638	-0.213	.001	.004	3	4
LUAD	GGCX →	+0.542	+0.233	<.001	<.001	3	4
HNSC	LRRC49 →	-0.584	-0.254	.004	<.001	3	4
BRCA	ZNF653 →	-0.376	-0.190	.009	.007	3	4
BRCA	CYP2D6 →	-0.538	-0.222	.002	.003	3	3
HNSC	PTOV1 →	-0.369	-0.244	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,202 associations by consensus.

RNF181 vs CHD6 — HNSC

Explore this scatter interactively →