RNF181

Across TCGA patient cohorts, RNF181 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF181-associated genes across cancer lineages are SOD1P2, MIR4516, and RNA5SP414. Each is linked with RNF181 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF181-to-partner and partner-to-RNF181 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOD1P2 grouped by RNF181-low versus RNF181-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF181→partner) and Y-score (partner→RNF181) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SOD1P2 →	+0.128	+6.018	<.001	.002	3	2
UCEC	MIR4516 →	+0.676	+3.748	<.001	.008	3	2
UCEC	RNA5SP414 →	+1.342	+3.840	<.001	.007	3	1
BLCA	LINC02741 →	+0.045	+5.411	.009	.005	3	1
BLCA	PISRT1 →	+0.088	+5.899	<.001	.002	3	1
BLCA	OR7A2P →	+0.053	+6.147	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

SOD1P2 by RNF181 expression — BLCA

Explore this box plot interactively →