RNF181

Across TCGA cell cohorts, RNF181 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,576 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RNF181-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Meiotic chromosome condensation, and DNA replication proofreading. Each is linked with RNF181 in more than 10 cancer types. Because this analysis shows association rather than direction, both RNF181-to-partner and partner-to-RNF181 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by RNF181-low versus RNF181-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF181→partner) and Y-score (partner→RNF181) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of chromosome condensation →	-0.162	-0.796	<.001	<.001	3	11
SOFT_TISSUE	Meiotic chromosome condensation →	-0.205	-0.855	<.001	<.001	3	10
BONE	DNA replication proofreading →	-0.202	-0.792	<.001	<.001	3	10
BONE	Nucleosome disassembly →	-0.171	-0.715	<.001	<.001	3	10
LARGE_INTESTINE	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation →	+0.115	+0.718	<.001	<.001	3	10
STOMACH	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.095	+0.979	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,576 associations by consensus.

Negative regulation of chromosome condensation by RNF181 expression — SOFT_TISSUE

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