RNF180

Across TCGA patient cohorts, RNF180 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF180-associated genes across cancer lineages are JNK_pT183_Y185, GATA6, and INPP4B. Each is linked with RNF180 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF180-to-partner and partner-to-RNF180 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by RNF180-low versus RNF180-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF180→partner) and Y-score (partner→RNF180) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.241	-3.156	<.001	<.001	3	3
UCEC	GATA6 →	-0.165	-1.899	.007	.016	3	2
UCEC	INPP4B →	-0.404	-3.584	.001	.002	3	2
UCEC	mTOR_pS2448 →	-0.136	-1.980	.019	.030	3	2
UCEC	ASNS →	+0.469	+2.000	<.001	.030	3	2
UCEC	ATM →	-0.467	-2.571	.008	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

JNK_pT183_Y185 by RNF180 expression — UCEC

Explore this box plot interactively →