RNF180

Across TCGA cell cohorts, RNF180 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF180-associated genes across cancer lineages are F9, R3HDML, and BANF2. Each is linked with RNF180 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF180-to-partner and partner-to-RNF180 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F9 grouped by RNF180-low versus RNF180-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF180→partner) and Y-score (partner→RNF180) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	F9 →	+0.032	+4.321	<.001	.009	3	1
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	BANF2 →	+0.047	+5.643	<.001	.002	3	1
LARGE_INTESTINE	CDX4 →	+0.007	+3.217	.001	.006	3	1
BLOOD_Leukemia	ITIH6 →	+0.021	+4.754	<.001	.002	3	1
BLOOD_Leukemia	C6orf118 →	+0.053	+3.450	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

F9 by RNF180 expression — CNS

Explore this box plot interactively →