RNF180

Across TCGA cell cohorts, RNF180 mutation is significantly associated with the mutation status of many other genes, with 3,671 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF180-associated genes across cancer lineages are ANKRD28, YLPM1, and MYO5C. Each is linked with RNF180 in more than 3 cancer types. Because this analysis shows association rather than direction, both RNF180-to-partner and partner-to-RNF180 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD28 grouped by RNF180-low versus RNF180-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF180→partner) and Y-score (partner→RNF180) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ANKRD28 →	+4.614	+4.614	.006	.006	1	4
BLOOD_Leukemia	YLPM1 →	+2.870	+3.347	.009	.009	1	4
BLOOD_Leukemia	MYO5C →	+3.115	+4.080	.001	.001	1	4
CNS	ZEB2 →	+4.614	+5.584	<.001	<.001	1	4
BLOOD_Lymphoma	SPEN →	+2.710	+4.203	.008	.008	1	4
LARGE_INTESTINE	WHRN →	+1.777	+2.963	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,671 associations by consensus.

ANKRD28 by RNF180 expression — CNS

Explore this box plot interactively →