RNF175

Across TCGA patient cohorts, RNF175 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF175-associated genes across cancer lineages are eIF4G, MEK1, and p62 Lck ligand. Each is linked with RNF175 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF175-to-partner and partner-to-RNF175 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by RNF175-low versus RNF175-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF175→partner) and Y-score (partner→RNF175) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.352	+3.000	.018	.036	3	1
UCEC	MEK1 →	+0.407	+3.169	.021	.019	3	1
UCEC	p62 Lck ligand →	+0.400	+2.459	.011	.020	3	1
UCEC	Rab11 →	-0.168	-2.459	.016	.020	3	1
UCEC	STAT3_pY705 →	-0.543	-3.449	<.001	.005	3	1
UCEC	VHL →	-0.979	-2.459	.002	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

eIF4G by RNF175 expression — UCEC

Explore this box plot interactively →