RNF170

Across TCGA patient cohorts, RNF170 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF170-associated genes across cancer lineages are p62 Lck ligand, Rad50, and TAZ. Each is linked with RNF170 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF170-to-partner and partner-to-RNF170 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by RNF170-low versus RNF170-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF170→partner) and Y-score (partner→RNF170) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.411	+2.321	.011	.035	3	1
UCEC	Rad50 →	-0.261	-2.321	.032	.035	3	1
UCEC	TAZ →	-0.149	-3.459	.036	.005	3	1
UCEC	TIGAR →	+0.155	+3.169	.043	.019	3	1
UCEC	14-3-3_beta →	-0.117	-3.149	.020	.019	2	1
UCEC	P-Cadherin →	-0.171	-3.446	.018	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p62 Lck ligand by RNF170 expression — UCEC

Explore this box plot interactively →