RNF168

Across TCGA patient cohorts, RNF168 mutation is significantly associated with the RNA expression of many other genes, with 672 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF168-associated genes across cancer lineages are RPS26P30, TXNL4AP1, and RPL36AP55. Each is linked with RNF168 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF168-to-partner and partner-to-RNF168 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS26P30 grouped by RNF168-low versus RNF168-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF168→partner) and Y-score (partner→RNF168) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RPS26P30 →	+0.108	+4.812	<.001	.006	3	3
CESC	TXNL4AP1 →	+0.127	+4.539	<.001	.008	3	2
CESC	RPL36AP55 →	+0.161	+5.595	<.001	<.001	3	2
UCEC	CYP27B1 →	+0.505	+3.724	.001	<.001	3	2
LUSC	CBX1P5 →	+0.144	+5.882	.002	.002	3	2
COAD	UBFD1P1 →	+0.115	+4.721	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 672 associations by consensus.

RPS26P30 by RNF168 expression — CESC

Explore this box plot interactively →