RNF168

Across TCGA cell cohorts, RNF168 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,353 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF168-associated GO terms across cancer lineages are DNA repair-dependent chromatin remodeling, Maintenance of centrosome location, and Regulation of DNA repair. Each is linked with RNF168 in more than 16 cancer types. Because this analysis shows association rather than direction, both RNF168-to-partner and partner-to-RNF168 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA repair-dependent chromatin remodeling grouped by RNF168-low versus RNF168-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF168→partner) and Y-score (partner→RNF168) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA repair-dependent chromatin remodeling →	+0.155	+1.152	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Maintenance of centrosome location →	+0.128	+1.347	<.001	<.001	3	16
BONE	Regulation of DNA repair →	+0.088	+1.075	<.001	<.001	3	15
SOFT_TISSUE	Double-strand break repair via nonhomologous end joining →	+0.050	+0.873	<.001	<.001	3	15
BONE	DNA recombination →	+0.078	+0.803	.008	.003	3	15
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via homologous recombination →	+0.079	+1.109	.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,353 associations by consensus.

DNA repair-dependent chromatin remodeling by RNF168 expression — BONE

Explore this box plot interactively →