RNF166

Across TCGA patient cohorts, RNF166 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF166-associated genes across cancer lineages are FOXO3a and Tuberin. Each is linked with RNF166 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF166-to-partner and partner-to-RNF166 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by RNF166-low versus RNF166-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF166→partner) and Y-score (partner→RNF166) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	+0.124	+2.820	.046	.036	3	1
UCEC	Tuberin →	+0.597	+2.817	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

FOXO3a by RNF166 expression — UCEC

Explore this box plot interactively →