RNF166

Across TCGA cell cohorts, RNF166 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,513 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF166-associated GO terms across cancer lineages are Signal transduction in response to DNA damage, Negative regulation of mRNA processing, and Anaphase-promoting complex-dependent catabolic process. Each is linked with RNF166 in more than 15 cancer types. Because this analysis shows association rather than direction, both RNF166-to-partner and partner-to-RNF166 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Signal transduction in response to DNA damage grouped by RNF166-low versus RNF166-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF166→partner) and Y-score (partner→RNF166) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Signal transduction in response to DNA damage →	+0.091	+0.951	<.001	<.001	3	15
OESOPHAGUS	Negative regulation of mRNA processing →	+0.137	+1.163	<.001	<.001	3	15
OESOPHAGUS	Anaphase-promoting complex-dependent catabolic process →	+0.094	+0.927	<.001	.004	2	16
BONE	Negative regulation of RNA splicing →	+0.081	+0.752	<.001	<.001	3	14
OESOPHAGUS	Negative regulation of mRNA splicing, via spliceosome →	+0.136	+0.968	<.001	.005	3	14
BONE	Nucleic acid transport →	+0.172	+1.126	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,513 associations by consensus.

Signal transduction in response to DNA damage by RNF166 expression — BONE

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