RNF165

Across TCGA cell cohorts, RNF165 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,800 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RNF165-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Cell surface pattern recognition receptor signaling pathway. Each is linked with RNF165 in more than 10 cancer types. Because this analysis shows association rather than direction, both RNF165-to-partner and partner-to-RNF165 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by RNF165-low versus RNF165-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF165→partner) and Y-score (partner→RNF165) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.145	+0.836	<.001	.004	3	11
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.147	+0.836	<.001	.004	3	10
SOFT_TISSUE	Cell surface pattern recognition receptor signaling pathway →	-0.086	-1.362	.001	<.001	3	9
OESOPHAGUS	Alternative mRNA splicing, via spliceosome →	+0.099	+0.832	<.001	<.001	3	9
OESOPHAGUS	Regulation of mRNA splicing, via spliceosome →	+0.089	+1.071	<.001	<.001	3	9
BONE	mRNA transport →	+0.142	+1.735	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,800 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by RNF165 expression — OESOPHAGUS

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