RNF157

Across TCGA patient cohorts, RNF157 mutation is significantly associated with the RNA expression of many other genes, with 1,139 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF157-associated genes across cancer lineages are RNU6-1111P, CYP2AB1P, and HIGD1AP9. Each is linked with RNF157 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF157-to-partner and partner-to-RNF157 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1111P grouped by RNF157-low versus RNF157-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF157→partner) and Y-score (partner→RNF157) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1111P →	+0.469	+3.906	.003	.004	3	3
LUAD	CYP2AB1P →	+0.074	+3.868	.005	.002	3	2
LUAD	HIGD1AP9 →	+0.209	+3.379	.006	.007	3	2
UCEC	MON1A →	+0.489	+3.332	<.001	.005	3	2
UCEC	NDUFAF2 →	+0.710	+3.470	<.001	.002	3	2
UCEC	DAGLB →	+0.487	+3.732	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,139 associations by consensus.

RNU6-1111P by RNF157 expression — LUSC

Explore this box plot interactively →