RNF151

Across TCGA patient cohorts, RNF151 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF151-associated genes across cancer lineages are eIF4G, SLC1A5, and Tuberin. Each is linked with RNF151 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF151-to-partner and partner-to-RNF151 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by RNF151-low versus RNF151-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF151→partner) and Y-score (partner→RNF151) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.432	+3.000	.015	.036	3	1
UCEC	SLC1A5 →	-0.552	-2.992	.024	.036	3	1
UCEC	Tuberin →	+0.489	+2.817	.001	.036	3	1
UCEC	ATM →	-0.785	-3.000	.002	.037	3	1
UCEC	Caspase-8 →	-0.324	-3.000	.025	.036	3	1
UCEC	Bap1-c-4 →	+0.253	+3.013	.045	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eIF4G by RNF151 expression — UCEC

Explore this box plot interactively →