RNF150

Across TCGA patient cohorts, RNF150 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF150-associated genes across cancer lineages are ASNS, eIF4E, and Gab2. Each is linked with RNF150 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF150-to-partner and partner-to-RNF150 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by RNF150-low versus RNF150-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF150→partner) and Y-score (partner→RNF150) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.417	+1.678	.001	.021	3	3
UCEC	eIF4E →	+0.246	+3.713	.001	<.001	3	2
UCEC	Gab2 →	+0.348	+2.459	.006	.018	3	2
UCEC	p70-S6K_pT389 →	-0.213	-2.459	.001	.018	3	2
UCEC	p90 RSK_pT359_S363 →	-0.183	-1.925	.012	.005	3	2
UCEC	PCNA →	+0.244	+3.807	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ASNS by RNF150 expression — UCEC

Explore this box plot interactively →