RNF150

Across TCGA cell cohorts, RNF150 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. CNS shows the largest number of these associations.

The most reproducible RNF150-associated genes across cancer lineages are SPAG11A, OR4C12, and EXOC1L. Each is linked with RNF150 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF150-to-partner and partner-to-RNF150 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPAG11A grouped by RNF150-low versus RNF150-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF150→partner) and Y-score (partner→RNF150) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPAG11A →	+0.104	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	EXOC1L →	+0.152	+3.544	<.001	.009	3	1
LARGE_INTESTINE	HSFY2 →	+0.013	+3.977	<.001	.001	3	1
CNS	UGT2B10 →	+0.052	+5.321	<.001	.005	3	1
CNS	OR1E2 →	+0.455	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SPAG11A by RNF150 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →