Across TCGA pan-cancer cohorts, RNF14P2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNF14P2’s most consistent transcriptional readouts.
The strongest signal is observed in cholangiocarcinoma (CHOL), where RNF14P2 RNA is repressed in tumor relative to normal tissue. In most cancer types RNF14P2 is over-expressed in tumor, although a few such as CHOL and KIRP show the opposite, repressed pattern.
CHOL and KIRP are the cancer types where RNF14P2 tumor–normal differential expression is most reproducible.