RNF149

Across TCGA pan-cancer cohorts, RNF149 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNF149 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher RNF149 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RNF149 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LIHC, SCLC, and ESCA are the cancer types where RNF149 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.051	0.783	<.001	36	view →
SCLC	OS	Median	II,III,IV	0.082	0.702	<.001	30	view →
ESCA	OS	Median	II,III,IV	0.136	0.703	<.001	18	view →
UCEC	DFS	Median	III,IV	1.000	0.535	.023	18	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RNF149–LIHC (OS)

Open the LIHC breakdown →