RNF149

Across TCGA patient cohorts, RNF149 mutation is significantly associated with the RNA expression of many other genes, with 1,690 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF149-associated genes across cancer lineages are OR10J6P, PER1, and MTUS2-AS1. Each is linked with RNF149 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF149-to-partner and partner-to-RNF149 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10J6P grouped by RNF149-low versus RNF149-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF149→partner) and Y-score (partner→RNF149) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR10J6P →	+0.070	+5.618	<.001	.002	3	2
UCEC	PER1 →	+0.720	+3.617	.002	.001	3	1
UCEC	MTUS2-AS1 →	+0.217	+3.610	.008	.003	3	1
UCEC	LDLRAD3 →	+0.735	+3.338	.004	.005	3	1
UCEC	GCC1 →	+0.588	+3.584	.003	.003	3	1
UCEC	ZNF746 →	+0.528	+3.491	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,690 associations by consensus.

OR10J6P by RNF149 expression — BLCA

Explore this box plot interactively →