RNF149

Across TCGA patient cohorts, RNF149 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF149-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and JNK2. Each is linked with RNF149 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF149-to-partner and partner-to-RNF149 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RNF149-low versus RNF149-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF149→partner) and Y-score (partner→RNF149) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.299	-3.000	.023	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.187	-3.000	.034	.036	3	1
UCEC	JNK2 →	+0.324	+3.009	.001	.019	3	1
UCEC	Ku80 →	+0.333	+2.183	.007	.035	3	1
UCEC	N-Cadherin →	+0.300	+2.817	.006	.036	3	1
UCEC	NDRG1_pT346 →	-0.615	-3.000	.016	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by RNF149 expression — UCEC

Explore this box plot interactively →