RNF148

Across TCGA patient cohorts, RNF148 mutation is significantly associated with the RNA expression of many other genes, with 1,505 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF148-associated genes across cancer lineages are RNA5SP307, RPL9P33, and SH3GL1P2. Each is linked with RNF148 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF148-to-partner and partner-to-RNF148 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP307 grouped by RNF148-low versus RNF148-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF148→partner) and Y-score (partner→RNF148) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP307 →	+0.290	+4.757	<.001	.004	3	2
CESC	RPL9P33 →	+0.108	+3.653	<.001	.009	3	2
UCEC	SH3GL1P2 →	+0.311	+2.364	<.001	<.001	3	2
UCEC	PRSS53 →	+0.347	+3.534	<.001	<.001	3	2
UCEC	MVD →	+0.763	+3.961	<.001	<.001	3	2
UCEC	DAPK3 →	+0.522	+2.839	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,505 associations by consensus.

RNA5SP307 by RNF148 expression — CESC

Explore this box plot interactively →