RNF148

Across TCGA patient cohorts, RNF148 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF148-associated genes across cancer lineages are EGFR, JNK2, and MEK1. Each is linked with RNF148 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF148-to-partner and partner-to-RNF148 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by RNF148-low versus RNF148-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF148→partner) and Y-score (partner→RNF148) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.149	-1.807	.023	.027	3	2
UCEC	JNK2 →	+0.223	+1.807	.006	.027	3	1
UCEC	MEK1 →	+0.398	+2.700	.008	.006	3	1
UCEC	p27_pT157 →	-0.048	-2.282	.043	.034	3	1
UCEC	p62 Lck ligand →	+0.327	+3.321	.014	.009	3	1
UCEC	Tuberin →	+0.345	+2.321	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

EGFR by RNF148 expression — UCEC

Explore this box plot interactively →