RNF148

Across TCGA cell cohorts, RNF148 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible RNF148-associated genes across cancer lineages are MAGEB5, PIRT, and TMCO5A. Each is linked with RNF148 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF148-to-partner and partner-to-RNF148 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by RNF148-low versus RNF148-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF148→partner) and Y-score (partner→RNF148) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PIRT →	+0.006	+4.643	<.001	.008	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MAGEB5 by RNF148 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →