RNF141

Across TCGA pan-cancer cohorts, RNF141 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RNF141 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RNF141 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RNF141 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where RNF141 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	1.000	0.589	.017	13	view →
LUAD	OS	Quartile	III,IV	0.445	1.000	.029	5	view →
HNSC	DFS	Tertile	IV	0.897	0.695	.019	4	view →
UCEC	DFS	Median	All	1.000	0.939	.039	4	view →
LSCC	DFS	Median	III,IV	1.000	0.867	.045	2	view →
GBM	OS	Tertile	All	0.956	0.799	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RNF141–CCRCC (DFS)

Open the CCRCC breakdown →